Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR)

Regulation of mRNA Expression of Xenobiotic Transporters by the Pregnane-X Receptor (PXR) in Mouse Liver, Kidney, and Intestine

The pregnane X receptor (PXR; also known as steroid and xenobiotic receptor, or SXR) is a nuclear hormone receptor activated by xenobiotics as well as diverse sterols

This article is available online at http://www.jlr.org The pregnane X receptor (PXR; also known as steroid and xenobiotic receptor, or SXR) is a nuclear hormone receptor activated by xenobiotics as well as diverse sterols and their metabolites ( 1–3 ). In the past decade, the role of PXR as a sensor that coordinately regulates xenobiotic clearance in the liver and intestine has been clearly est...

Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by posttranslational modification of PXR protein.

Human UDP-glucuronosyltransferase (UGT) 1A1 is a critical enzyme responsible for detoxification and metabolism of endogenous and exogenous lipophilic compounds such as bilirubin. The present study shows how cyclin-dependent kinase (CDK) inhibitor roscovitine stimulated the expression of UGT1A1 in HepG2 cells. Pregnane X receptor (PXR)-mediated transactivation of UGT1A1 reporter gene was more pr...

CXR , a novel xenobiotic - sensing orphan nuclear receptor is related to both mammalian pregnane X receptor ( PXR ) and constitutive androstane receptor ( CAR )

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR).

Nuclear receptors constitute a large family of ligand-modulated transcription factors that mediate cellular responses to small lipophilic molecules, including steroids, retinoids, fatty acids, and exogenous ligands. Orphan nuclear receptors with no known endogenous ligands have been discovered to regulate drug-mediated induction of cytochromes P450 (CYP), the major drug-metabolizing enzymes. He...